CDIO is on behalf of Conceive, Design, Implement and Operate. The carrier of CDIO engineering education philosophy is a project which allows students to take the initiative, practical, organic link between the curriculums for learning. E-Business specialty has a property combination of management and engineering. Therefore, with CDIO educational philosophy, to promote E-Business specialty and industry associated, to improve innovation and practical ability for Management talent for Applied, is the current employment situation and development trend of higher education, and a useful attempt to improve teaching quality construction. This paper analyzes of the current status of E-Business specialty and the implementation feasibility of E-Business specialty reform based on CDIO education,gives a innovative training model based on CDIO in Chengdu University of Information Technology.