This paper examines the integration of process inquiry and the case method in the study of IS failure. Having acknowledged the prevalence of IS failure and the need for continued inquiry in this domain the two predominant methods of enquiry, failure factor studies and IS failure case studies, are described along with the utility of both methods. The paper then examines the nature of case study research and notes its utility for the study of IS failure in real life settings. The nature of process inquiry is then examined and its applicability for the study of IS failure as a process is noted. The paper then describes how process inquiry is integrated with the case method as a six stage approach for conducting a case inquiry incorporating narrative, mechanisms, and other process-based data analysis methods.