Recently, social aspects of information Systems (IS) implementation has received increased attention of the researchers. Consequently, organizational culture and leadership roles also emerged as key areas of investigation for the researchers focusing on improving the effectiveness of IS implementation. However, previous studies have largely ignored the relationship between leadership and IS implementation. This study aims to go some way to fill in this gap in the literature. This research aims to investigate how leadership and organizational culture together affect the implementation of IS. For simplicity, this research takes Customer Relationship Management (CRM) as a case of IS implementation. However; the findings of this research will be applicable to IS implementation in general. This research will be based on interpretivist philosophy. Data for this research will be collected using expert interviews. Data will be analyzed using content analysis.