Information Systems (IS), nowadays often focusing on digitization, and their effect on employment have been discussed for a long time. The net effect resulting from job creation and job loss has never been clear. However, it seems obvious that today's information systems the accompanying digitization of data and processes may destroy jobs among knowledge workers just as automation did in the class of manufacturing workers. In this position paper, we outline the effects and mechanisms underlying digitization-driven job destruction and propose a research program to also take into account and prepare for the detrimental side of digitization.