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The world has become an open or 'flat' place. Information Systems (IS) students who graduate may wonder where their qualifications will take them in this world. How could they use it to make the most of it? And for those who want to venture into a higher degree, what can they expect in this new venture? I believe with Madni that [t]he time has come for us to begin for (sic) exploiting the 'flatness' of this world with open minds and a commitment to transdisciplinary research and education, the next frontier in the intellectual and societal growth of human kind (2007:10). This paper explores transdisciplinarity in IS by means of a literature review in order to come to a better understanding of the concept and I hope that it could make a small contribution towards the academic debate.