Building on multiple theoretical perspectives, we examine how organizational culture moderates the association of different dimensions of Internet-enabled Supply Chain Integration (i.e., online information sharing and operational coordination) and firm performance (i.e., operational and customer service performance). We test hypotheses using survey data from senior executives in China. Our findings reveal that an internally focused culture negatively moderates the effects of information sharing on both operational and customer service performance. In contrast, an internally focused culture positively moderates the relationships between operational coordination and firm performance. In addition, our findings indicate that an externally focused culture negatively moderates the effects of operational coordination on customer service performance. Theoretical contributions and managerial implications of the study are discussed.