This paper introduces how Fink’s Integrated Course Design model was used to refine a Health Information Technology (HIT) core course – "Clinical Process and Workflow: Analysis and Redesign" – for improving the design and enhancing student learning in this rapidly growing field. The paper describes the course design process centered on Fink’s taxonomy of significant learning – foundational knowledge, application, integration, human dimension, caring, and learning how to learn. Example case study assignment, term project and assessment rubric are provided. Student feedback shows that the course enhances student learning and prepares them to meet the needs of healthcare organizations and HIT development.