Mobile Learning (M-Learning) is no longer a novelty. Thousands of post-secondary education institutions and millions of workforce and distance-education students worldwide consider M-Learning a mainstream, pervasive, learning delivery mode. It is a different and alternate approach to Face-to-Face, Distance Learning (D-Learning), and Electronic Learning (E-Learning). A gap exists in the literature regarding the effectiveness of M-Learning. It is important to evaluate this learning delivery mode against Face-to-Face learning. This study examines M-Learning effectiveness vis-à-vis Face-to-Face and investigates the extent to which students accept the delivery of learning conducted through this new paradigm. A quasiexperimental research design is proposed to determine the impact of M-Learning on student performance and to uncover factors that influence user acceptance of M-Learning.