In this study, we developed a five-step process for GIS-enabled site location determination in different domains. We applied that process to a real case study to examine its feasibility. The case was about determination of a suitable location for a children-oriented store in Bannock County, Idaho. We used ArcGIS 10, went through the decision making process, considered several decision criteria, and determined the best location for that store. The process that we developed in this study can also be used in other contexts such as health care, banking, and tourism.