To date, few IS researchers have made use of multi-level modeling in their studies. This is unfortunate because organizational processes often span multiple levels of the organization. As such, multi-level modeling (MLM) has the potential to enhance our understanding of how IS can be deployed and used effectively in organizations. To this end, this paper reflects on the use of MLM in IS research. We illustrate the pertinent issues and challenges involved by describing how the widely used organizational level construct “Assimilation” will change conceptually and operationally if it is extended to the interorganizational level. Based on our analysis we conclude that while MLM is not a panacea, or appropriate for all research questions, identifying and including higher-level constructs in IS research models offers rich opportunities for IS research.