Enrollment growth has been a concern for many Management Information Systems (MIS) programs in recent years even though the job market remains strong. This paper investigates the factors that impact business students when they select their major and students’ perceptions of the MIS program. Students enrolled in business programs within a medium-size public university in the southeastern US participated in the study. Consistent with previous studies, this research finds that career-related and personal interest factors have the biggest impact on students’ choice of major. The implications of the study and strategies for promoting the MIS major are discussed.