Radio frequency identification (RFID) technology can be the initiator of a domino effect. To an organization, the adoption and deployment of RFID technology and the resulting influx of data, information, and knowledge will impact not only its IT infrastructure, but also the quality and timeliness of its business intelligence and decision making. This paper first provides an introduction to RFID technology and surveys a variety of its applications. Then it examines and discusses in detail the effects of RFID on an organization’s IT infrastructure, business intelligence, and decision making. It also discusses propositions, which can serve as a basis for the development of specific hypotheses to be empirically tested in future studies. Finally, it provides a conceptual research framework that illustrates the domino effect initiated by the use of RFID technology.