Information systems (IS) analysis and design has much to do with “people factors.” Basically, human beings are creatures of self-interest. This paper first proposes a theory of self-interest as the theoretical base and integrative approach to understand the phenomenon of IS development. Based upon the theory proposed, a series of research propositions are then advanced to lay the basis of specifying variables and hypotheses in future research. The two research questions explored are: (1) How does IS analysis and design connote self-interest? (2) How does self-interest affect IS quality?