This paper proposes a framework for electronic medical record (EMR) system implementation. Currently, the medical industry is experiencing a rapid increase in computerization. The medical companies are trying to improve and streamline business processes, which is leading to organizational changes. More and more physicians communicate with their patients by means of a desktop, notebook or pocket PC. On the way to a paperless medical office IS/MIS organizations need to create trustworthy communication environments, in which all communications are through computers, not pens and paper. This research suggests a trustworthy framework of an EMR system, which provides a solution to the problems of secure on-line transmission of electronic signatures (e-signatures), attached to medical documents. The experimental model proposes a set of conceptual variables.