Chronic diseases are known as the main cause of poor health, disability, death, and account for most of healthcare expenditures in developing countries. Thus, preventive care is identified as one of the most effective strategy to reduce the risk of chronic diseases and healthcare spending. Furthermore, the adoption of Hospital Information System (HIS) for preventive care is recognized to be an important resource towards addressing the problem of the rising of the healthcare costs and decreasing in quality of care. However, healthcare organizations do not consistently utilize the available resources for prevention of chronic diseases. The issues of underutilised resources, inadequate resources and inappropriate use of resources lead to lack of preventive care. Therefore, this study adopts both Resource Based View (RBV) and resource orchestration perspective to develop a conceptual model to study the influence of IS resources in HIS adoption towards hospital preventive care performance. This paper will contribute to the RBV theory, by applying resource orchestration as a theoretical lens to investigate complex interaction among IS resources towards organization performance and to provide important insights to the hospital management on how to resolve the issues concerning resources.