Hardware, software, network and data are a part of the components required in IT infrastructure in an organization for their day-to-day operation. To run and execute the IT infrastructure, an organization needs to allocate some amount of money to maintain and/or add and/or remove any of the components whenever required. As most organizations spend quite a lot of money for it, perhaps it will be an added value if any part of the IT infrastructure is flexible or agile. If there are any changes required at any time and the IT infrastructure is flexible, it will be no more constrain to the organization. Besides, any changes, demands, requests, customizations, etc. from customers towards certain product/services, changing direction or business objectives, to accommodate technology invention and innovation and also to follow current trends, it can be done and fulfilled easily, efficiently and effectively. This makes the organization relevant in the current global market. To compete with other organizations, the organization itself must ensure which information systems should be in place and/or which one to be maintained. This leads the managers or decision makers to maximize their ability, capability, wisely and strategically use of information systems in assisting them to direct, evaluate, guide and suggest for better decision making. Therefore, this study attempts to measure the impact of IT infrastructure flexibility on strategic use of information systems. Determinants of IT infrastructure flexibility use in this study are Human, Technical and Process IT infrastructure, meanwhile dimensions use to measure strategic use of information systems are product differentiation, cost leadership and growth advantage. This study would like to investigate among MSC status company in Klang Valley, Malaysia.