Telemedicine has great potential to improve health care in Sub-Saharan Africa. Yet resistance from healthcare professionals could prevent telemedicine’s social value from being materialized. This article intends to understand why users resist the use of telemedicine by investigating antecedents of resistance. A research was developed to propose that user resistance is determined by perceived threat and perceived controllability, which in turn are influenced by reduced autonomy, anxiety, and costs. In addition, we examine how government support can be mobilized to alleviate the inhibiting factors that lead to resistance. A survey on 107 healthcare professionals in Ethiopia provides support to most of the hypotheses.