Building on multiple theoretical perspectives, we examined how organizational culture moderates the relationship between power, trust, and a firm’s eSCMS adoption intention. We tested the hypotheses using survey data collected from senior executives in China. Our findings reveal that a target firm’s perceived mediated power would negatively impact its trust toward a dominant firm, while its perceived non-mediated power would positively affect its trust. Meanwhile, trust can positively influence the target firm’s eSCMS adoption intention. Further, an internally focused culture weakens the negative effects of mediated power on trust. Meanwhile, an externally focused culture weakens the positive relationships between non-mediated power and trust, and between trust and eSCMS adoption intention. The externally focused culture could weaken the negative relationship between mediated power and trust either. The theoretical contributions and managerial implications of the study are discussed.