In the current information age, information can make a difference to all aspects of one’s life, emotionally, eth ically, financially or societally . Information privacy plays a key role in enabling a difference in many dimensions such as trust, respect, reputation, security, resource, ability, employment, etc. The capability of information to make a difference to one’s life is a fundamental factor; and privacy status of information is a key factor driving this difference. Understanding the impact of these two factors to one’s life within an IS context is an import ant research gap in the discipline. This paper studies “information + privacy”, ontologically and integrally, in making a difference to one’s life, within the IS context. In recognition of the importance of the Privacy- by -Design approach to IS development, a methodology is proposed to understand the grounds of information and model fundamental constructs for using Privacy- by - Design approach to develop robust privacy - friendly information systems.