Since 1987, universities have been acknowledged as having the potential to make a crucial contribution to addressing the challenges of sustainability. Although many universities have attempted to make contributions towards sustainability at some level, few have succeeded in realizing their potential to make significant contributions in research, education or as adopters of sustainable practices within their institutions. This paper aims to assist universities to improve their contributions to the challenges of sustainability by clarifying the drivers and inhibitors of organizational initiatives and by proposing a model of IS- enabled innovation for universities to promote renewed efforts. An IS research agenda is proposed that is integrated with the model of IS-enabled organizational innovation to support adoption and diffusion of IS-enabled innovation in this domain.