The introduction of hospital information systems (HIS) into the hospital environment has brought profound changes to the healthcare system around the world. Through an in-depth case study with one of the model digital hospitals in China, this study explores some key factors impacting HIS adoption. To get a holistic view of the HIS adoption process, three different inter-connecting adoption phases were considered in the study, which include the adoption decision making stage, the system implementation stage and the system assimilation stage. The lessons learned from the HIS adoption experiences of the case hospital offer contributions to both theory and practice, particularly within the context of technology adoption within the healthcare sector.