With the advances in Information Technology (IT), the potential of IT in enabling enterprise agility has received increasing attention from practitioners and the academia in recent years. However, despite the recent advance of knowledge on agility and IT innovation, the relationship between the adoption of IT and enterprise agility is often treated as a “black box” and empirical validation of the relationship between IT and enterprise agility is still scare. Moreover, the importance of agility in healthcare sector has largely been ignored. Our study proposes a three-stage process model that describes and analyzes the ways how agility and innovative capabilities are implemented and managed during the innovation of healthcare IT in a hospital. Theoretical and practical contributions were shared and documented in this paper.