Building on multiple theoretical perspectives, we examined how organizational culture moderates the association of different dimensions of Internet-enabled Supply Chain Integration (i.e., online information integration and operational coordination) and firm performance (i.e., customer service and financial performance). We tested hypotheses using survey data from senior executives in China. Our findings reveal that an internally focused culture weakens the effects of online information integration on customer service performance, whereas it strengthens the influences of online operational coordination. Further, an externally focused culture weakens the effects of online operational coordination on customer service performance too. In addition, the results indicate that customer service can directly improve financial performance, and partially mediate the relationship between online information integration and financial performance. Theoretical contributions and managerial implications of the study are discussed.