This study is a design science research which describes the design of a radio frequency identification (RFID) based Healthcare Management System (RHMS) for the healthcare industry. In this study, a prototype RHMS has been designed and developed. The evaluations results validate the practical viability of the proposed architecture. We have described an Information System Design Theory for the RHMS which can form a basis for further research. We hope that the lessons learned from this study help support and further the efforts of academicians, researchers and practitioners in RFID based healthcare management system research.