This study proposed a comprehensive decomposed TPB model to understand the factors influencing the intentions of individual professionals to use information technology. A field survey was conducted to collect analysis data from physicians who have used Medline system, a kind of evidence-based medicine database, in Taiwan. After the research model was tested by the partial least square method with bootstrap estimate, we found that decomposed TPB provides effective prediction of physicians' acceptance intention of the Medline system. Comparing to subjective norm and perceived behavioral control, attitudes towards using the IS provide better predictive power for behavioral intention. In addition, perceived usefulness and perceived ease of use have significant impact on attitude, respectively. Perceived ease of use has significant impact on perceived usefulness. The variance of subjective norm can be effectively explained by interpersonal influence. Personal innovativeness in IT not only directly influences perceived behavioral control, but also indirectly influences perceived behavioral control through self-efficacy. However, the facilitating conditions have no significant effect on perceived behavioral control. These findings not only provide insights for further research related to information technology acceptance by individual professionals, but also offer medical institutions practical suggestions.