The adoption of inter-organisational system (IOS) has become important for many organisations to increase the efficiency of their business operations and to stay competitive. IOS adoption offers significant benefits to organisations at various levels including operational, tactical and strategic levels. While previous studies have identified a number of factors that affect the achievement of IOS benefits by organisations, little is known about the relationships between these factors to the achievement of different types of IOS benefits. In this study, we use two case studies in large Australian pharmaceutical and grocery manufacturing companies to demonstrate that there is a relationship between factors and types of benefit. A number of propositions are developed to guide further research.