This paper discusses the significance of mixed methods research in information systems (IS) research. Mixed methods research allows a more holistic view in studying information systems (IS). It is useful in understanding the information systems world which is both social and natural in nature to present a full picture of the phenomenon. Mixed methods research therefore removes the limitation of the traditional approaches as one approach’s weakness is complemented by the other approach’s strength. The mixed methods research rationale is that no single research approach is sufficient by itself to capture the breadth and depth of complex IS research. This study is guided by the following question: What is the significance of mixed methods in information systems research? This paper therefore argues that mixed methods research provides an escape for IS researchers from the trap of seeing research as a single research design instead of benefiting from the best of both worlds.