Information System (IS) tools and applications create opportunities for a positive digital change to all individuals and organizations in the global workplace to improve competitiveness and quality of work life. Recent studies have shown that the most problematic areas in IS security incidences are people-related factors. In this regard, employees are causing IS security risks and vulnerabilities as they use those resources, especially by exercising their legitimate and lawful rights, mainly because people are the weakest link on IS security matters. On the one hand, the effects of organizational sanctions are not always effective due to socio-cultural variabilities, and so far they have not been able to fully defend employee related IS misuse or misconduct. On the other hand, the use of neutralization techniques supports individuals to justify their deviant actions, but differently to people in different socio-cultural bases. To examine such a problem, therefore, culture as a moderator, criminological constructs and level of employees’ awareness to IS security as independent variables are employed to explain IS misuse intention in unison are proposed through a comprehensive conceptual research model. A positivist research paradigm using a cross-sectional quantitative survey data collection approach will be adapted to help empirically test the model. To validate the model and its constructs, the study will apply SEM-PLS data analysis techniques using Smart-PLS and SPSS with Amos. Finally, this study in progress discusses the potential practical and theoretical contributions and plans to provide scientific evidence based on its findings.