This work aims at investigating the relationship between two major concepts in current research on working environment and working conditions, work flexibility and ICT use. Specifically, our aim is to demonstrate that an increase in work flexibility relies on higher levels of ICT use, coherently with the diffused idea that new technologies should be structurally and intrinsically flexible and their use in work means greater flexibility. In order to pursue our goal, a definition of work flexibility is provided in the first part of the paper, along with a review of current literature linking more recent contributions within those two areas of study. Hypothesis are then suggested to test. In the second part, the results of an analysis - carried out on a sample of European employees (N=34.885) taken from the European Working Conditions Survey (EWCS) - are reported. In the final part, the first evidence emerging from the study is discussed, underlying its unexpected features, and concluding remarks on the managerial implications of our enquiry are reported, along with the principal limits and future perspectives of further analysis.