E-government has increasingly been adopted globally by governments in order to enhance the provision of services to citizens and promote inclusive governance. It is perceived that E-government has the potential to significantly improve government-citizen interaction by providing equal access to government services for all citizens. Lack of equal access to E-government services has emerged as one major setback of E-government in achieving its objectives. Studies in E-government have documented how E-government can act as a tool for exclusion particularly for persons with disabilities (PWDs) an already marginalized group if accessibility barriers are not addressed. Developing countries however, have received little attention in this regard which calls for a greater concern; since 80% of the world’s disabled population reside here. Few studies that have been conducted in the developing countries fail to integrate PWDs into the digital society. This calls for the need to examine how researchers conduct studies on E-government accessibility towards PWDs, the research approach they adopt and the understanding they gain of the phenomenon. This paper present findings based on systematic literature review with the purpose of identifying key research foci, methodologies and theoretical perspectives used when studying E- government accessibility for PWDs particularly in developing countries.