This paper investigates the information practices of different professionals in a distributed and interdisciplinary work process. Specifically, it looks at how a collection of information artefacts, both electronic and paper based, is used in the process. To conceptualize heterogeneous and collective artefacts in use, this paper draws on the literature on information infrastructures and on recent development in Actor-Network Theory. The empirical material presented comes from an interpretive case study on the heart transplant process in a large hospital in Norway. The paper discusses how the information infrastructure in use in this process works coherently according to multiple logics of information use. The findings are related to the nature of technology as complex object in use and their relevance is discussed in relation to change processes in hospitals.