In today’s knowledge economy, organizations need to effectively manage their knowledge to support an increasing number of knowledge intensive business processes. Such knowledgeintensive business processes could be more effectively supported by Process-based knowledge management (PKM) systems that integrate knowledge management services with process management systems. However, currently there are minimal design guidelines for developing such PKM systems. In this research-in-progress paper, we highlight this research problem, and propose a preliminary framework that can be extended to serve as a design theory for developing process-based knowledge management systems. Specifically, we identify kernel theories governing the design and development of PKM systems, and propose a design process for developing PKM systems. We also identify future research opportunities for further extending the framework and its evaluation.