This research-in-progress article reports on an ongoing investigation that explores the transition from RFID-enabled transactional systems to RFID-enabled strategic systems in healthcare settings. By adopting a comparative case study approach and a process oriented perceptive, this research explores the underlying causal mechanisms that shape transition processes in this ever important industry. By developing deep insight into the factors that shape transition processes in healthcare, our research aims to generate key findings that are useful for both academic and practitioner audiences. By informing thinking in these areas, we hope to assist healthcare organizations in leveraging the strategic advantages offered by RFID technologies.