This paper examines the recent claim that “technologies remain largely understudied in organizational research”. The core contention is that the materiality of the IT artefact has been ignored, thus contributing to an impoverished understanding of the relationship between technology, people and organisation. While accepting much of the criticism directed towards the “isolation of technology”, this paper sets out to develop a basis from which the concept of materiality may be fruitfully developed by outlining a structure of mediation based on the work of Don Ihde and Peter-Paul Verbeek. In discussing the role of mediation, the paper claims that much of the literature on Clinical Information Systems has failed to address the ‘substitution of bodies’ and the ‘de-centred patient’, thus providing a fertile environment for a promising research agenda in Information Systems Materiality.