The aim of this paper is to contribute to the discussion about the utilization and enactment of information systems development (ISD) methodologies in development projects. To contribute to the scientific documentation of methodology enactment, we provide an empirically grounded study of the practical use of development methodologies in a project, in which, on the basis of a defined systems development methodology, a process unfolded that resulted in the development of a multimedia information system (MMIS). On the basis of understanding the enactment of methodology as organizational innovation, we present an integrative framework, which allows us to investigate the relation between individual actors, structural elements, and the interactive process of systems development in practice. This results in a richer understanding, shows how the methodology emerged in practice, and provides a basis for reflecting on that emergence in order to draw lessons about systems development practice and theory.