The deployment of large-scale information systems is a major trend in the corporate world today due to a number of driving forces such as the Internet, globalization, and the use of IT for distributed knowledge. However, the adaptation process of such new technologies is not yet well understood. With its theoretical basis on structuration theory and actor network theory (ANT), this study employs a case study methodology with organizations implementing ERP systems and investigates how the technological adaptation of large-scale IS, specifically ERP systems, differs from that of traditional (standalone) IS. Our findings are expected to have both theoretical and practical implications for the design as well as implementation of large-scale IS.