Social media (SM) applications have played a critical role for the rapid dissemination of information during the COVID-19 pandemic. Limited insight is provided into the main reliable SM source for information and awareness about the pandemic. This study examines the role of SM applications in creating awareness during the pandemic in Saudi Arabia. The study used a quantitative approach and distributed an online questionnaire via SM platforms during October 2020 and received 343 valid responses from university students, healthcare professionals, and the public. Findings showed that despite the wide use of SM applications, the MOH website was the main source of information relied upon during the pandemic. Gender differences were found on the reliance of SM platforms for information. Developing SM policies and best-practice guidelines are necessary to better perceive SM applications as effective public health educational sources and awareness channels during crises.