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With the strong advocacy of national policies and the rapid development of electronic commerce, offline logistics operation has become the key to efficient and fast e-commerce. This paper will use the system dynamic method to build an integrated warehousing and distribution system of e-commerce, applying the computer simulation to analyze the change of each parameter after the target inventory and delay time have changed. Suggestions will be put forward at last: building of an info-sharing mechanism, reducing the delay time via active coordination, predicting the target inventory of distribution center on time. Through these to reduce the average cost and the possibility of short supply at distribution center, and thus guarantee the delivery quality and speed, optimize buyers’ shopping experience, form a virtuous circle and enhance the overall competence of the supply chain.