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The Internet of Things (IoT) perceives and recognizes the physical world by taking advantage of smart devices. The world’s largest minority are people with disabilities. IoT can lower barriers for the disabled people in accessing information. Increasing Internet accessibility can help to make that happen for both social and economic benefit. This paper presents the proposed integrated framework of the IoT and cloud computing for people with disabilities such as sensory (hearing and vision), motor (limited use of hands) and cognitive (language and learning disabilities) impairments in the context of business-to-consumer (B2C) e-commerce context. We conclude that IoT-enabled services offer great potential for success of disabled people in the context of e-commerce.