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In view of rising micro-blogging, the searchers of health information have increased dramatically anywhere in Taiwan. The purpose of this study was designed to refine and apply the theory of health belief model and tried to explore significant affected factors on the Plurkers behavior in tracing the health information. The survey methodology of this study administered the online questionnaire procedure during a two-week period in May, 2010. The effective respondent numbers totally are 233. Moreover, the multiple regression method was also used to analyze the results. After statistical analysis, the critical finding points out that majority of micro-blogging users acquiring the health information was mainly affected by the factors of Social Influence, Trust and Perceived Barriers. Hence, the professional and convenient information might be provided for us to promote the intention of use in Plurk.