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This paper highlights the case study organisation of the National Science and Technology Development Agency (NSTDA) as a learning organisation. As NSTDA seeks to provide effective mechanisms for supporting smalland medium-sized enterprises (SMEs), it recognises the importance of knowledge as a mechanism for generating innovations. Thailand realises the importance of science and technology (S&T) for economic development, wealth creation and improvement in the quality of life. It is setting the direction and gaining commitment towards knowledge-based economy through the National Economic and Social Development Plans and phased programmes. In its effort to achieve this aim, the National Science and Technology Development Agency (NSTDA) plays a major role in propelling the national knowledge competence for social and economic development.