This Delphi study identifies problems that have significant impacts on profits gained from large engineering and construction projects in a European company. Information quality gained remarkable weight among the identified problems. The problems were ranked in accordance to their estimated impact on the project profit margins. Within a consolidated list of 125 problems identified altogether, the final ranking of the top 18 problems was strongly agreed upon by an expert panel. The panel involved experienced engineering and management professionals throughout the construction project supply chain. Among the top 18, eight problems, including the top six, concerned information quality. The results address a need for increased focus on information quality challenges in the target organization and provide a detailed account of such challenges in comparison to the previous literature on information quality in engineering and construction.