Information systems development (ISD) affects individual workers, organizations (e.g., computerization of work places and quality of work) and the surrounding society (e.g., reliability and safety of software). It is relevant to consider social responsibility of those who design and implement information systems (IS) because of these effects of ISD. We combine results of studies on bases of orientations of ISD team members and the literature on responsibility to provide ISD team members with guidelines. These guidelines aim to develop team members’ sense of responsibility by focusing on the ISD process, the product itself and this product in the practice context. The guidelines are finally linked to IS education and practice of ISD, and recommendations for future research are presented.