In this exploratory paper, we analyse the packaged software industry, focussing specifically on usability issues associated with geographical/societal, sector and organisational cultures. We point to the different groupings that may constitute the ‘communication’ and ‘task localisation’ challenges associated with the roll out of globally standardised packages across and within diverse cultural settings. Our reading of the situation suggests several points of common interest between those engaged in Human Computer Interaction and Information Systems research. In particular: how the usability of products may be proffered in the processes of selection, implementation and use; usability based ethical considerations in the packaged software industry and contexts of use; the idea of ‘best culture’ and a wider conceptualisation of usability that goes beyond those features inscribed in the software. In conclusion, we argue that although only exploratory in nature, our work points to the value of this form of analysis in respect of other information and communication technologies. Moreover, we feel that our collaboration evidences the utility in fostering interdisciplinary relations between Human Computer Interaction and Information Systems.