The development of e-interactions (IT supported business interaction) need to be facilitated by comprehensive frameworks for business interaction. Existing frameworks cover fragments of the important constituents of business interaction. Based on a review of existing frameworks a more comprehensive one is presented in this paper. This comprehensive framework builds upon a symmetric focus on a supplier and on a customer. Attention is directed towards both communicative and material/financial exchanges. It distinguishes between different levels (markets level and dyadic level) of business interaction and acknowledges the dynamics of business interaction as the continual development of capabilities and business relations. On the dyadic level a distinction is made between frame contracting and business transaction. The proposed framework should be and has been used for evaluating, modelling and designing e-interactions.