In this paper we present a system for agent-based support of clinical processes. We describe the basic engineering concept, along with specific simulation and testing scenarios for agent-based software engineering. Another important focus is the integration of existing agent or healthcare standards like FIPA, DICOM and HL7. Objectives of our research activities in this project are: a substantial increase of the efficiency of hospital process management as well as the development of a specific goal oriented requirements engineering methodology. As most important challenges of the healthcare domain we have identified on the one hand individualized, patient oriented processes in diagnostics, therapy, nursing and administration and on the other hand extremely distributed decision processes and strong local (individual) autonomy with a high degree of situational dynamics. The example scenario on „clinical trials“ illustrates how the system shall support distributed clinical processes and how it interacts with other multiagent systems within the Agent.Hospital Framework and hospital information systems in the eHealth Lab introduced in this paper. The system development is part of the German Priority Research Program (SPP) 1083 “Intelligent Agents and their application in business scenarios”.