This paper questions the influence of a pre-existing information technology (IT) infrastructure on the formulation of an organizational knowledge strategy. We draw on a classification of four different strategic views of IT infrastructure and explore how the historic investment in IT infrastructure enables and constrains the formulation of knowledge strategy in four case organizations. The four case organizations are representative of different scenarios of historic investments in IT infrastructure and knowledge strategy formulation. Our findings indicate that an IT infrastructure that is minimal or fragmented constrains the formulation of an explicit knowledge strategy. We further find that an extensive existing IT infrastructure enables the pursuit of an explicit knowledge strategy, but that even an elaborate IT infrastructure can introduce some constraints on IT facilitated knowledge processes in the organization.