Giddens' structuration theory is increasingly used in studies assessing IT-based organizational change. However, few studies, if any, have focused on how to empirically apply this “meta-theory”. In this article, over twenty IS studies published in the last ten years which used structuration theory were reviewed. We extend previous research by analyzing the strengths and weaknesses of different methodological strategies adopted by IS researchers using structuration theory. The main contribution of this article is a repertoire of methodological strategies to empirically apply structuration theory in the IS field.