This paper examines the key issues in software product and interface localization, including the cost and the specific aspects of software that must be localized, and a methodology for analyzing and documenting software localization. Software localization is the process by which computer applications are analyzed and adapted to the requirements of different markets. The paper is based on a review of relevant literature, meetings with localization industry representatives, and an ongoing participant observation in a global telehealth company. Examples from the company illustrate the localization issues and their possible outcomes or solutions. Several research studies in the area of localization are identified in the conclusion of the paper.