Information systems (IS) research has always been one of the leading applied research areas in the investigation of technology-related phenomena. Meanwhile, for the past 10 years, artificial intelligence (AI) has transformed every aspect of society more than any other technological innovation. Thus, this is the right time for IS research to foster more quality and high-impact research on AI starting by organizing the cumulated body of knowledge on AI in IS research. We propose a framework called AI capability framework that would provide pertinent and relevant guidance for conducting IS research on AI. Since AI is a fast-evolving phenomenon, this framework is founded on the main AI capabilities that shape today’s fast-moving AI ecosystem. Thus, it is crucial that such a framework engages both AI research and practice into a continuous and evolving dialogue.